Selank research overview
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was designed as an analog of tuftsin, the tetrapeptide Thr-Lys-Pro-Arg found in the heavy chain of immunoglobulin G, lengthened at the C-terminus by the tripeptide Pro-Gly-Pro. Most of the published work comes from the Institute of Molecular Genetics in Moscow.
Selank is not approved by the FDA for any use. Pep Shop Texas supplies it as a lyophilized powder for laboratory research only.
Identity and structure
| Name | Selank (tuftsin analog, TKPRPGP) |
|---|---|
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) |
| Length | 7 amino acids |
| Molecular formula | C33H57N11O9 (free peptide) |
| Molecular weight | about 751.9 g/mol (free peptide); the acetate salt is heavier |
| CAS number | 129954-34-3 |
| Form | White lyophilized powder in a sealed vial |
Published research
Published Selank studies are mostly gene-expression work in rats and mice. The papers below are listed by what was measured. They are not evidence of safety or effect in people.
Mouse spleen tissue. Measured mRNA levels of inflammation-related genes after Selank administration.
Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011;170(1-3):18-23. PubMed 21609736
Rat frontal cortex, 1 and 3 hours after a single administration of Selank or GABA. Measured mRNA levels of 84 neurotransmission-related genes by real-time RT-PCR array.
Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Front Pharmacol. 2016;7:31. PubMed 26924987
Storage of lyophilized material
Keep lyophilized Selank sealed, dry and away from light. Supplier data sheets give -20 °C (a standard freezer) for long-term storage of the powder. Let a cold vial reach room temperature before opening it so moisture does not condense on the powder.
Lab testing
Each batch Pep Shop Texas sells is sent to an independent lab for identity (LC-MS) and purity (HPLC) testing. See the product page for the current certificate. How we test.
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For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or supplement. Pep Shop Texas is not a compounding pharmacy and does not give dosing or preparation guidance. Nothing on this page is medical advice or a claim about use in people.