CJC-1295 research overview
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH). It is built on the hormone's first 29 amino acids, GRF (1-29), with four substitutions (D-Ala2, Gln8, Ala15, Leu27) that make the chain more resistant to breakdown by enzymes such as dipeptidyl peptidase-IV.
As first described by ConjuChem in 2005, CJC-1295 also carries an extra lysine at the C-terminus with a maleimidopropionyl group (the Drug Affinity Complex, DAC) that binds covalently to serum albumin. The same 29-residue peptide without that group is sold as CJC-1295 without DAC, also called modified GRF (1-29). The two forms differ in formula and molecular weight, listed below.
CJC-1295 is not approved by the FDA for any use. Pep Shop Texas supplies it as a lyophilized powder for laboratory research only.
Identity and structure
| Name | CJC-1295 (tetrasubstituted GRF (1-29); without DAC also called modified GRF (1-29)) |
|---|---|
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 |
| Length | 29 amino acids (C-terminal amide); the DAC form adds a modified lysine |
| Substitutions vs. GRF (1-29) | D-Ala2, Gln8 (for Asn), Ala15 (for Gly), Leu27 (for Met) |
| Molecular formula | C152H252N44O42 without DAC; C165H269N47O46 with DAC |
| Molecular weight | about 3368 g/mol without DAC; about 3647 g/mol with DAC |
| CAS number | 446262-90-4 (CJC-1295 with DAC, as listed in PubChem) |
| Form | White lyophilized powder in a sealed vial |
Published research
Published CJC-1295 work includes in-vitro, rat and mouse studies from its development, and later clinical studies. This page lists the laboratory and animal work, by what was measured. It is not evidence of safety or effect in people.
Three maleimide-bearing GRF (1-29) analogs, bound to human serum albumin ex vivo, tested in cultured rat anterior pituitary cells and in male rats. Measured stability against DPP-IV, GH secretion in vitro and in plasma, how long the analog stayed in plasma, and its binding to albumin by Western blot.
Jetté L, Léger R, Thibaudeau K, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058. PubMed 15817669
GHRH-knockout mice over 5 weeks, against untreated knockout and heterozygous controls. Measured body weight and length, femur and tibia length, body composition, pituitary RNA and GH mRNA, and somatotroph cells by immunohistochemistry.
Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. PubMed 16822960
Storage of lyophilized material
Keep lyophilized CJC-1295 sealed, dry and away from light, in a freezer (about -20 °C) for long-term storage of the powder. Let a cold vial reach room temperature before opening it so moisture does not condense on the powder.
Lab testing
Each batch Pep Shop Texas sells is sent to an independent lab for identity (LC-MS) and purity (HPLC) testing. See the product page for the current certificate. How we test.
CJC-1295: strengths, price and stock · All lab reports · A–Z index · Full collection
For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or supplement. Pep Shop Texas is not a compounding pharmacy and does not give dosing or preparation guidance. Nothing on this page is medical advice or a claim about use in people.