BPC-157 research overview
BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide: a chain of 15 amino acids whose sequence is a partial sequence of a protein described in human gastric juice. It is made by solid-phase peptide synthesis and supplied as a lyophilized (freeze-dried) powder.
BPC-157 is not approved by the FDA for any use. The material Pep Shop Texas sells is for laboratory research only.
Identity and structure
| Name | BPC-157 (Body Protection Compound 157, pentadecapeptide BPC 157) |
|---|---|
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV) |
| Length | 15 amino acids |
| Molecular formula | C62H98N16O22 |
| Molecular weight | about 1419.5 g/mol |
| CAS number | 137525-51-0 |
| Form | White lyophilized powder in a sealed vial |
Published research
Most published BPC-157 work is preclinical: cultured cells, tissue explants and rodent models, much of it from one research group in Zagreb. The studies below are listed by what was measured. They are not evidence of safety or effect in people.
Rat Achilles tendon explants and cultured tendon fibroblasts. Measured fibroblast outgrowth, proliferation (MTT), survival under hydrogen peroxide stress, transwell migration, F-actin formation and FAK and paxillin phosphorylation.
Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011;110(3):774-780. PubMed 21030672
Chick chorioallantoic membrane assay, endothelial tube formation in vitro and a rat hind-limb ischemia model. Measured vessel density, blood flow by laser Doppler, VEGFR2 expression and internalization, and VEGFR2-Akt-eNOS signaling.
Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med. 2017;95(3):323-333. PubMed 27847966
Review of the group's rodent studies, comparing BPC-157 with standard angiogenic growth factors across gastrointestinal, tendon, ligament, muscle and bone models.
Seiwerth S, Rucman R, Turkovic B, et al. BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Curr Pharm Des. 2018;24(18):1972-1989. PubMed 29998800
Storage of lyophilized material
Keep lyophilized BPC-157 sealed, dry and away from light. Supplier data sheets give -25 to -15 °C (a standard freezer) for long-term storage of the powder. Let a cold vial reach room temperature before opening it so moisture does not condense on the powder.
Lab testing
Each batch Pep Shop Texas sells is sent to an independent lab for identity (LC-MS) and purity (HPLC) testing. How we test.
BPC-157: strengths, price and stock · All lab reports · Full collection
For laboratory research use only. Not for human or veterinary use. Not a drug, food, cosmetic or supplement. Pep Shop Texas is not a compounding pharmacy and does not give dosing or preparation guidance. Nothing on this page is medical advice or a claim about use in people.